Bio‐Inspired Formal Synthesis of Hirsutellones A—C Featuring an Electrophilic Cyclization Triggered by Remote Lewis Acid‐Activation.

A bio-inspired strategy is used to complete the formal synthesis of the antitubercular hirsutellone B (I) and congeners A (II) and C (III), through construction of its decahydrofluorene core from a linear polyene strand activated at both ends by a silyl enol ether and an allyl acetate (not shown).