The Effect Of Pregabalin On Bone Metabolism

Abstract Introduction/Background The aim of the study was to determine the effect of pregabalin as monotherapy on biochemical markers and bone mineral density. Methods 40 patients diagnosed with neuropathic pain or fibromyalgia syndrome who were using pregabalin for at least 6 months and age and sex matched 40 healthy individuals were recruited for this cross-sectional study. Bone mineral density of both groups were measured by dual energy x ray absorbsiometry(DXA), bone biochemical markers, serum calcium and vitamin D levels were investigated. Association between pregabalin use and bone biochemical markers, serum calcium, vitamin D levels were evaluated. Results The mean age of 40 patients (27 females, 13 males) was 40.6±7.1 years and the mean age of 40 healthy individuals (27 females, 13 males) was 40.4±7.3 years. The other demographic data were similar. There were no significant differences in lumbar and femur neck BMD scores between two groups. Also, there were no associations neither between pregabalin use and biochemical markers including serum calcium levels nor between pregabalin use and vitamin D levels. However the patients who had been used pregabalin less than 24 months had low lumbar t and z scores than patients who had been used pregabalin more than 24 months. This effect was more prominent in male patients. Conclusions Although no negative effect of pregabalin was found on bone metabolism in these group of patients, we have suggested that further prospective controlled studies with large sample size in different age groups could provide new data about the effects of pregabalin on bone metabolism. We suggest to investigate the bone metabolism especially in male patients on pregabalin treatment who had been used pregabalin treatment less than 24 months.