Statistical Appraisal of 6 Recent Clinical Trials in Cardiology: JACC State-of-the-Art Review

Highlights •This review is a constructive critical appraisal of key recent cardiology trial reports. •The trials are CABANA, ATTR-ACT, COAPT, DECLARE, REDUCE-IT, and AUGUSTUS. •For each study, the main findings are documented and interpreted. •Particular attention is paid to new findings, their research context, and study limitations. •Topical examples provide methodological insights pertinent to future clinical trials research.