An aggressive histologic phenotype in young breast cancers in India: A correlational study.

e11043 Background: Breast cancer patients younger than 40 years are known to have an aggressive disease than their older counterparts. In this correlational study involving Indian women with breast cancer; we analyzed if age is related to an aggressive histopathologic phenotype and biomarker expression. Methods: Paraffin embedded tissue blocks of hundred chemotherapy naive breast cancer patients with a diagnosis of invasive breast carcinoma were stratified for age group (less than forty and above forty years) equally from the hospital biorepository. Tissue samples were analyzed for pathological stage, histological type, ER, PR and Her2 Neu receptor status, and expression of biomarkers such as Ki67, EGFR and P53 using immunohistochemistry. Data were analyzed using Chisquare test for proportions. Results: Younger age group had significantly higher grade (p=0.03), higher incidence of solid (p=0.04) and micropapillary type DCIS (p=0.004), ER negativity (p=0.04), higher proliferation rate as indicated by over ...