Clinicopathological features and immunohistochemical studies of 12 cases low-grade endometrial stromal sarcoma

Objective To explore the clinicopathological features and immunohistochemical characteristics of low-grade endometrial stromal sarcoma.Methods The clinical and pathological data of 12 cases were retrospectively analyzed,and combined with immunohistochemistry.Results Patients with clinical manifestations of the uterus tumor and vaginal bleeding were misdiagnosed as uterine leinmyoma or ademomyosis before surgery.Diagnosis was mainly confirmed by pathologic results after surgery.Among the 12 cases,there was 1 case with sex-cord differentiation and 1 case with mixed smooth muscle tumor.There were 2 cases with uterine adenomyoma and 4 cases with multiple uterine leinmyoma.Histologically,tumor cells consisted of infiltrative and diffuse round or ovary cell.LGESS was typically composed of similar with proliferative endometrial mesenchymal cells with obvious small helix arteries and presented invasion reaching the uterine muscular layer.Immunohistochemistry showed the tumor cells were CD10(++++),vimentin(++++),ER(+),PR(+++),CK5/6(-~+),EMA(-~+),S-100 and CD34(-).The vascular endothelial cells were positive for CD34 in tumor tissue.Conclusion It is difficult to confirm LGESS before surgery,but the combination of clinicopathological features and immunohistochemical markers help us make the correct diagnosis.