Chronic mucocutaneous candidiasis and alopecia areata as cutaneous expressions of autoimmune polyglandular syndrome type I

Sir, investigations did not display non-organ-speci Ž c autoantibodies or autoantibodies to adrenal gland, thyroid, Autoimmune polyglandular syndromes (APS) are hereditary disorders classiŽ ed into APS types I, II and III parathyroid and gastric parietal cells. Furthermore, autoantibodies to steroidogenic enzymes, such as steroid in accordance with several endocrine and non-endocrine failures or defects (1). Chronic mucocutaneous candidi17a-hydroxylase, cytochrome P450 side-chain cleavage enzyme and steroid 21-hydroxylase , were not detected asis, alopecia areata and vitiligo variously complete the clinical picture of these syndromes (1). using immunoprecipitation assay. Only anti-insulin and anti-pancreatic islet cell antoantibodies were found. The A case of APS type I showing chronic mucocutaneous candidiasis and alopecia areata is described, with these patient is receiving replacement therapies for endocrinological failures and systemic anti-fungal therapy skin disorders outlined as cutaneous typical expressions of this syndrome. (itraconazole 200mg/day for 2 months) resulting in a substantial improvement of candida infections.