The influences on carbohydrate-deficient transferrln level in healthy individuals after short term alcohol intake

Objective To discuss the variation trends of carbohydrate-deficient transferrin (CDT) level and other alcohol related tests in healthy individuals after short term alcohol intake. Methods Examinees took alcohol for one week at a certain amount. The level of CDT, transferrin (Tf), CDT%, gamma-glutamyl-transferase(GGT), ALT, AST, AKP, Fe and glucose was checked before and after drinking, and one and two weeks after stopping drinking. The examinees were grouped according to their gender, smoking and drinking histories. All items mentioned above were compared among groups. Results Reference interval was 33.6±13.0 mg/L(mean±2SD). The levels of CDT and COT% were (33.6±6.6) mg/L (mean± SD), (1.4±0.2)% (mean±SD) at the before dinking, (39.9±9.0) mg/L, (1.6±0.4)% at the after drinking, (36.2±6.7) mg/L, (1.5±0.2)% at the one week after drinking and (32.3±8.8) mg/L, (1.4±0.3) % at the two weeks after drinking. There were significant differences in serum CDT and CDT% between pre-drinking and post-drinking, one week after stopping drinking(CDT: t value=-9.1,-5.1, P 0.05; CDT%:t value=2.5, P>0.05). However, there were no significant differences among groups according to gender, smoking and drinking histories at the pre-drinking, after drinking, one weeks after stopping drinking and two weeks after stopping drinking. The levels of AKP are (64.1±19.9) U/L (mean±SD) at the before dinking, (65.3± 16.9) U/L at the after drinking, (76.9±20.4) U/L at the one week after drinking and (64.9±16.4) U/L at the two weeks after drinking. AKP level reached peak value one week after stopping drinking. The difference was significant (t value=-6.704, P<0.01) between the levels of AKP at the after drinking and at the one week after stopping drinking. Conclusions The levels of Serum CDT and CDT% reached peak value after stopping drinking and returned to basic level two weeks after stopping drinking. They were not influenced by gender, smoking and drinking histories. They could serve as monitoring indexes for recent drinking status on healthy individuals. Key words: Transferrin;  Gamma-glutamyltransferase;  Alanine transaminase;  Liver diseases;  alcoholic