OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3

TGFβ signalling through SMAD proteins controls many different processes, both during embryonic development and in adult tissues. Herhaus et al. show that the deubiquitinase OTUB1 promotes TGFβ signalling by binding specifically to activated SMAD2/3 complexes and inhibiting their ubiquitiylation.