Association of SLCO 1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients

Laura B. Ramsey,Halima Moncrieffe,Chelsey N. Smith,Marc Sudman,Miranda C. Marion,Carl D. Langefeld,Mara L. Becker,Susan D. Thompson

Association of SLCO 1B1 *14 Allele with Poor Response to Methotrexate in Juvenile Idiopathic Arthritis Patients

2019

Laura B. Ramsey
Halima Moncrieffe
Chelsey N. Smith
Marc Sudman
Miranda C. Marion
Carl D. Langefeld
Mara L. Becker
Susan D. Thompson

Objective Variants in the SLCO1B1 gene, encoding a hepatic methotrexate (MTX) transporter, affect clearance of high‐dose MTX. We tested whether in the *14 and *15 alleles of SLCO1B1 influenced the response to low‐dose MTX in juvenile idiopathic arthritis (JIA) patients.

Keywords:

Gastroenterology
Juvenile
Methotrexate
Arthritis
Internal medicine
Allele
Medicine
Leukemia
Dosing
Tumor necrosis factor alpha
Single-nucleotide polymorphism
SLCO1B1

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