Pseudocapsule-based transsphenoidal microsurgery for pituitary microprolactinoma

Objective To study the clinical significance of pseudocapsule in the transsphenoidal microsurgery for pituitary microprolactinoma.Methods From March 2012 to May 2013,61 patients with microprolactinoma were prospectively grouped and treated with pseudocapsule-based extracapsular transsphenoidal microsurgery,and the clinical and follow-up data were retrospectively analyzed.Results All the patients were followedup for 10 months in average.59 cases (96 ％) regained regular menstruation,33 (94％) with galactorrhea had relieved,15 experienced postoperative pregnancy.The preoperative mean value of serum prolactin was 7.66 nmol/L and the postoperative was 0.42 nmol/L.According to the comprehensive evaluation of symptomatic,endocrinological and radiological indexes,the early total remission rate achieved to 96％.There was no severe complication.Conclusions The outcome of pseudocapusle-based extracapsular microsurgery for pituitary microprolactinoma was significant,and the complication was rare.Transshpenoidal microsurgery was the first line treatment for microprolactinoma with poor response or intolerance to bromocriptine. Key words: Prolactinoma;  Microsurgery;  Pseudocapsule;  Extracapsular resection