Foveal Avascular Zone Measurement Via Optical Coherence Tomography Angiography and its Relationship with the Visual Field in Eyes with Open-angle Glaucoma.

PReCIS:: The foveal avascular zone in optical coherence tomography angiography is significantly correlated with retinal inner layer thickness, Humphrey field analyzer 10-2 sensitivity threshold, and mean deviation value in open-angle glaucoma patients. PURPOSE: To measure the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) and investigate its relationship with retinal inner layer thickness and visual field defects in eyes with open-angle glaucoma (OAG). PARTICIPANTS AND METHODS: A total of 52 eyes with OAG from 52 patients. FAZ area was measured using OCTA in angio-macula mode. Thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer plus inner plexiform layer (GCL+IPL), and ganglion cell complex (GCC) were determined using a 750% shaded blockmm x 750% shaded blockmm macular (V) map via 3D-OCT. Correlations of FAZ area with sensitivity threshold measurements, foveal threshold (FT), and mean deviation (MD) value in the HFA10-2 visual field were analyzed for each inner retinal layer. RESULTS: FAZ area was 0.26+/-0.0750% shaded blockmm; overall mean thicknesses were 19.14+/-6.5550% shaded blockmum (RNFL), 57.34+/-5.9350% shaded blockmicrom (GCL+IPL), and 75.87+/-10.9650% shaded blockmum (GCC); mean FT was 35.23+/-3.1550% shaded blockdB, and sensitivity threshold was 20.81+/-7.2250% shaded blockdB in the HFA 10-2 visual field. FAZ area was significantly correlated with thickness of individual retinal layers in the entire field (RNFL, P<0.001; GCL+IPL, P<0.001; GCC, P<0.001), sensitivity threshold (P=0.01), FT (P<0.001), and MD value (P=0.011). CONCLUSIONS: FAZ area was significantly negatively correlated with retinal inner layer thickness, sensitivity threshold, FT, and MD value in the HFA10-2 visual field.