Effect of 2 referral intervals on diagnostic discordance between cytology and histology at a colposcopy clinic.

Abstract Objective To determine the effect of the time interval between cervical cytology screening and histology at treatment on grade of cervical disease. Methods In a retrospective cross-sectional study at a colposcopy clinic in Soweto, Johannesburg, South Africa, data were compared from women with cytologic abnormalities referred for colposcopy between April 2003 and June 2010 to determine whether early (≤ 180 days) or late (> 180 days) referral had an impact on dysplasia grade. Results In the early and late referral groups, there were 213 (13.43%) and 201 (14.63%) women, respectively, with upgrading of cervical dysplasia ( P  = 0.35), and 1373 (86.57%) and 1173 (85.37%) women, respectively, with downgrading or no change ( P  = 0.35). Risk factors for upgrading were HIV infection (odds ratio [OR], 1.63; P P  = 0.02). Four cases (0.68%) of invasion among women with low-grade squamous intraepithelial lesion (LSIL) and 50 cases (2.11%) among women with high-grade SIL (HSIL) were not detected by cytology. Risk factors for invasive disease on histology were age (OR, 1.09 per year; P P P  = 0.03). Conclusion There was no difference in the up- or downgrading of cervical dysplasia between the 2 referral groups.