The clinical effect of montelukast combined with budesonide aerosol in the treatment of children with cough variant asthma

Objective To observe the clinical efficacy and safety of montelukast combined with budesonide in the treatment of children with cough variant asthma(CVA).Methods 76 cases with CVA were randomly divided into two groups,two groups were treated with terbutaline,discontinuation of the drug after remission of symptoms.38 cases in the observation group were treated with montelukast combined with budesonide,38 cases in the control group were treated with budesonide.All the children were treated for 3 months.The clinical curative effect was compared between the two groups.Follow-up for 6 months,the incidence of adverse reactions and recurrence were observed.Results The total effective rate of observation group was 97.37％,which was higher than that in the control group 86.84％,the difference between the two groups was statistically significant(P＜0.05).The adverse reactions occurred in 2 cases(5.26％)of observation group,5 cases(13.16％)in the control group.The incidence of adverse drug reaction rate was slightly lower than that of control group,but the difference was not significant(P＞0.05).The observation group had 1 case recurrence(2.63％),the control group 2 cases of recurrence(5.26％),the difference between the two groups was not statistically significant(P＞0.05).Conclusion Montelukast combined with budesonide inhalation in treatment of children with CVA has significant efficacy,adverse reactions are mild,low recurrence rate. Key words: Asthma; Montelukast and budesonide; Child