The Effect of Cisplatin-Etoposide Chemotherapy on Platelet Parameters in Lung Cancer Patients -

The aim of this study was to investigate the effect of cisplatin etoposide chemotherapy on platelet indices in advanced stage lung cancer patients. Twenty advanced stage lung cancer patients who received cisplatin and etoposide chemotherapy and 35 healthy subjects were enrolled. The platelet indices (platelet count, mean platelet volume (MPV), plateletcrit (Pct) and platelet distribution width (PDW)) and other blood count parameters were recorded in baseline, before second cycle and after sixth cycle of chemotherapy. In baseline analysis, white blood cell count, but not other blood parameters, were different in patient group compared with control group,. After six cycles of chemotherapy, PDW values were elevated than baseline analysis in lung cancer patients. Other platelet parameters were not changed after chemotherapy. This study showed that MPV, platelet count, or Pct don’t change after cisplatin-etoposide chemotherapy in lung cancer patients.