Biological and pharmacological effects of gamma-oryzanol: an updated review of the molecular mechanisms.

BACKGROUND Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties such as antioxidant, anti-inflammatory, anticancer, anti-diabetic, ameliorating menopausal unpleasant symptoms, cholesterol-lowering, plasma lipid pattern improving, etc. Methods: In this study we reviewed the scientific literature published up until 2020, which have evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct and Scopus. RESULTS & CONCLUSION The present review attempts to summarize the most related articles about the pharmacologic and therapeutic potential from recent studies on γ-oryzanol to gain insights for design further studies to achieve new evidence which confirm observed effects.