Total Synthesis of Hoiamide A Using an Evans–TishchenkoReaction as a Key Step
2019
The first total synthesis of neurotoxic cyclodepsipeptide hoiamide A (1) has been accomplished. The synthesis features the use of an Evans–Tishchenko fragment coupling between a five-stereogenic-center-containing β-hydroxyketone and a chiral aldehyde derived from threonine.
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