Growth hormone-releasing factor-induced growth hormone secretion from perifused rat anterior pituitary cells: lack of influence of glucose concentration, and normal responses in pituitary cells from diabetic animals

The mechanism responsible for the suppression of GH secretion in hyperglycaemia and hypoglycaemia in rats has been investigated using perfusion of anterior pituitary cells. When perifused with Krebs-Ringer bicarbonate containing normal high and low concentrations of glucose, the GH responses to GH-releasing factor (GRF) were respectively compared with the initial response to GRF at 5 mmol/l in each column