[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. New therapeutic target for rheumatoid arthritis.]

For rheumatoid arthritis, biological DMARDs, such as TNF inhibitors, and JAK inhibitors have been widely used as a targeted therapy. These drugs show higher effect compared to conventional therapy. New molecular targeted drugs are also developing. Clinical trials of anti-GM-CSF and -chemokine monoclonal antibodies, and inhibitors of intracellular signals are underway. We anticipate new drugs with higher efficacy and safety.