Triphenyltin Fluoride (TPTF) as a Diabetogenic Agent: TPTF Induces Diabetic Lipemia by Inhibiting Insulin Secretion from Morphologically Intact Rabbit B-Cell

Recent work in our laboratory has shown that oral administration of triphenyltin fluoride (TPTF) evokes hypertriglyceridemia in rabbits. The present experiments were conducted to elucidate the mechanism of TPTFinduced hypertriglyceridemia in rabbits by a combined biochemical and ultrastructural approach. After a single TPTF administration, fasting blood glucose and plasma triglyceride levels increased significantly (P