Direct Regioselective γ-Amination of Enones.
2016
Carbonyl compounds bearing a γ-amino group are valuable pharmacologically active targets. Regioselective γ-C–N bond formation is achieved with simple enone substrates through controlled dienolate reactivity toward azodicarboxylate electrophiles. The amination reaction occurs readily with sterically demanding nucleophiles and is stereoselective.
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