Multiple sclerosis-associated uveitis

ABSTRACTIntroduction: Multiple sclerosis (MS)-associated uveitis is an uncommon ocular manifestation of the systemic neurological disease. A wide range of ocular findings has been described including uveitis from every anatomical location. Most commonly, MS-associated uveitis presents as a chronic bilateral intermediate type of uveitis. Although the underlying mechanism remains unknown, a relationship between MS and uveitis suggests autoimmune and genetic predispositions. This manuscript aims to update the clinician on the multiple clinical portraits as well as the latest therapeutic advances in the field.Areas covered: The authors systematically describe the epidemiology, the pathophysiological hypotheses, the clinical manifestations, and the treatment options of MS-associated uveitis. A thorough literature review of the last 10 years was conducted using PubMed.Expert commentary: Limited literature is currently available on MS-associated uveitis. To date, the presence of MS-associated uveitis is not cons...