Application of TCT detection combined with HPV genotyping in cervical lesion screening

Objectives:To study the clinical application value of high risk human papilloma virus(HR-HPV) test combined with thin-prep cell test in screening cervical precancerous lesions.Methods:432 women patients who were admitted into our hospital from January,2012 to December,2012 were screened by HR-HPV test and thin-prep cell test.Directed biopsies under colposcopy were taken and analyzed.Results:80 cases of TCT were positive,with the infection rate of 18.15%.45 cases of pathology test were positive,with the coincident rate of 66.17%;116 of 432 cases were HR-HPV positive with the infection rate 26.85%.53 cases of pathology test were positive,with the coincident rate of 77.94%;58 cases were HR-HPV + TCT positive,with the coincident infection rate of 85.29%.The differences of the coincident rates were statistically significant(P 0.05).Conclusions:Cervical intra-epithelial neoplasia and cervical cancer detection rates could be improved by TCT combined with high risk HPV detection,which can provide scientific basis for early diagnosis.It is of great significance to have regular TCT and HPV test to lower the HPV infection rate and to decrease the incidence of cervical lesions and cervical cancer.