Palladium-Catalyzed and Alcohol-Enabled Transformation to Synthesize Benzocyclic Ketones

Catalytic carbonyl formation ranks as one of the most important synthetic methodology. Herein, a highly effective palladium-catalyzed and alcohol-promoted transformation of nitrile to synthesize benzocyclic ketones is described. It allows for straightforward access to potentially valuable indanone compounds in high yields in the presence of alcohol. It avoided the usage of carbon monoxide or additional hydrolysis procedure.