Prevalence of Hepatitis B Virus in Primary Central Nervous System Lymphoma (P07.009)

OBJECTIVE: The aim of this study is to establish Hepatitis B Virus (HBV) serological statuses in a retrospective cohort of Primary Central Nervous System Lymphoma (PCNSL) patients. BACKGROUND: PCNSL is a particularly rare B cell Non-Hodgkin lymphoma (NHL), strictly localized in the brain, the leptomeninges, the eyes and the spine. In the immunocompromised patients, PCNSL is frequently associated with Epstein Barr Virus. Up to date, no association between this brain tumor and viruses has been pointed out in immunocompetent patients. Nevertheless, there are growing evidences that systemic B-NHL might be associated with HBV and Hepatitis C Virus (HCV). DESIGN/METHODS: The medical records of 106 immunocompetent patients who were treated in our department between 2002 and 2012 for PCNSL were reviewed. RESULTS: The sex ratio of the cohort was 1.3 (60 males/45 females) and the median age was 62 years (range: 16-84). None of the patients were infected by HCV. HBs Ag, anti-HBs Ab and anti-HBc Ab were detected in 2.8% (n=3), 29.2% (n=31) and 15.1% (n=16) of cases respectively. Although prevalences of HBsAg and anti-HBc Ab were not significantly different from what was observed in the greater Paris area (e.g. Ile de France) population (2.8% vs. 0.8%; p=0.07 regarding HBsAg; 15.1% vs. 10.8%; p=0.2 regarding anti-HBc Ab), there were a trend for higher HBsAg and anti-HBc Ab seroprevalences in PCNSL. CONCLUSIONS: This is the first study investigating Hepatitis virus infection in PCNSL patients. Although trends were observed, no statistically significant difference was found regarding prevalence of HBs Ag or anti-HBc Ab compared to the control population. Further studies using additional control population and enrolling a larger number of patients will be needed to study the association between HBV infection and PCNSL and the potential role of HBV in the development of these rare tumors. Disclosure: Dr. Faivre has nothing to disclose. Dr. Thibault has nothing to disclose. Dr. Houillier has nothing to disclose. Dr. Sanson has nothing to disclose. Dr. Delattre has nothing to disclose. Dr. Hoang Xuan has nothing to disclose. Dr. Idbaih has nothing to disclose.