Diurnal Measurements of Macular Thickness and Vessel Density on OCT Angiography in Healthy Eyes and Those with Ocular Hypertension and Glaucoma.

PRECIS Macular superficial capillary plexus and thickness are reduced in eyes with glaucoma and ocular hypertension but do not change significantly during the day. No relationships with age, intraocular-pressure, systemic hypertension, or axial length were found. PURPOSE To evaluate diurnal differences in retinal thickness and vessel density (VD) of the macular superficial (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA) among three groups of eyes: eyes with glaucoma, eyes with ocular hypertension, and healthy eyes. METHODS A consecutive series of individuals was recruited prospectively. OCTA was performed in the morning and in the evening. RESULTS Forty eyes from 23 individuals with glaucoma (58.35±6▒y), 52 eyes from 32 individuals with ocular hypertension (58.84±7▒y), and 73 eyes from 44 controls (57.84±6▒y) were enrolled. Morning and evening measurements of all SCP-VD and retinal thickness parameters were statistically significantly different (P 0.19). A positive linear correlation in diurnal changes was found between SCP-VD and DCP-VD in the fovea and in the parafovea (r = 0.5567 and r = 0.5892, respectively) and between SCP-VD and retinal thickness in the fovea and in the parafovea (r = - 0.2288 and r = 0.2418, respectively). CONCLUSION Macular SCP-VD and thickness are reduced in eyes with glaucoma and ocular hypertension. Although diurnal changes in SCP-VD, DCP-VD, and macular thickness were not significant among the groups, some linear correlations in increasing or decreasing values of the investigated parameters were found.