Severe proteinuria as a parameter of worse perinatal/neonatal outcomes in women with preeclampsia

Abstract Objectives The present study aimed to determine the relationship between the severity of proteinuria and maternal/neonatal outcomes among women with preeclampsia. Study design Proteinuria severity was measured at preeclampsia diagnosis and at delivery in 94 women with preeclampsia (among 2904 women with singleton pregnancies, who delivered after 22 gestational weeks). Preeclampsia was defined as hypertension with proteinuria. Main outcome measures Protein:creatinine (P/C) ratio to worse the maternal outcome was 4.8 among women with preeclampsia. Results The frequencies of HELLP syndrome and maternal pulmonary edema in women with a P/C ratio ≥5.0 (35.5% and 35.5%, respectively) were significantly higher than those in women with a P/C ratio Conclusions A higher P/C ratio at delivery in women with preeclampsia might cause EPB and CSC.