Hypo-Estrogenemia in retinal vasculopathy due to primary antiphospholipid antibody syndrome

PURPOSE. To report hypo-estrogenemic state in a case of recurrent vitreous hemorrhages due to primary antiphospholipid antibody syndrome. METHODS. Interventional case report. A 40-year-old woman presented with recurrent vitreous hemorrhages. Treated initially with laser photocoagulation followed by hormone replacement therapy. RESULTS. Cessation of vitreous hemorrhage since starting hormone replacement therapy (twenty months ago). CONCLUSIONS. This is the first documented case of hypo-estrogenemia in lupus anticoagulant retinopathy. The response of this condition to estrogen is worth exploring.