Zerebrale Hämodynamik bei Kohlendioxidapplikationen

Cerebral Hemodynamics in Carbon Dioxide Applications Introduction: We compare the effect of carbon dioxide (CO2) dry and wet applications on cerebral hemodynamics. Methods: On 22 volunteers measurements were taken during CO2 application. 10 probands were examined in CO2 wet application (1,100–1,300 mg/l) and 12 probands in CO2 dry application (500 g in a 800 l bathtub). The cerebral blood flow velocity (CBFV) in the middle cerebri artery (MCA) was measured as a parameter of cerebral hemodynamics by means of transcranial doppler sonography. Furthermore were recorded CO2 expiratory concentration (CO2et), blood pressure, and sublingual temperature. Results: At CO2 wet application the CBFV increased during therapy phase by 15% (p = 0.001), parallel to the rise of the CO2et by 18% (p = 0.01). During CO2 dry application CBFV decreased by 11% (p = 0.007), body temperature increased significantly by 0.2 °C. Conclusion: CO2 applications have influence on cerebral hemodynamics. Assuming constant diameters of the great brain vessels, CO2 wet application shows a raising and CO2 dry application a reducing influence on cerebral blood flow. This influence will attain therapeutic relevance.