Effects of Shenfu Qiangxin Pills on Myocardial Cells Bcl-2 Expression and Anti-heart Failure Mechanism in Abodominal Aortic Coarctation Rats

Objective:To investigate the effects of Shenfu Qiangxin pills on myocardial cells Bcell lymphoma/leukemia-2(Bcl-2) expression and anti-heart failure mechanism in abodominal aortic coarctation rats.Method:The rats model of chornic cardiac failure(CHF)were made by abdominal aortic banding.The ventricular pressure wave,limb leads electrocardiogram(EKG),neuroendocrine,myocardial cells apoptosis,myocardial fibrosis of coarctation of aorta rat were determined.Result:The left ventricular pressure peak(LVSP),+dp/dtmax,-dp/dtmax were depressed(P0.05,P0.001,P0.001),indicating ventricular systolic function decreased.left ventricular end diastolic pressure(LVEDP) was raised(P0.001).ST of EKG was raised(P0.05),QRS were extended(P0.05).Angiotensin Ⅱ(AngII) and aldosterone(ALD) in blood plasm were increased(P0.01,P0.01).Myocardial cellular structure was damaged.The Bcl-2 expression was down-regulated.Fibrosis was tested under microscope.Shenfu Qiangxin 2.14 g · kg-1 improved ventricular systolic and diastolic function.The +dp/dtmax and-dp/dtmax were raised significantly compared with the model group(P0.01,P0.05).The LVEDP and ST of EKG were improved significantly(P0.001,P0.05).AngII and ALD in blood plasm were depressed.The myocardial cellular structure,Bcl-2 expression and fibrosis in the Shenfu Qiangxin groups were improved significantly.Conclusion:Shenfu Qiangxin can improve cardiac function function,and up-regulate.,Bcl-2 expression.