Microdose computed tomographic cardiac angiography in normal cats.

Abstract Objectives To determine if microdose contrast-enhanced multi-detector computed tomographic angiography (MDCTA) allows characterization of cardiac chambers in lightly sedated normal cats. Animals Seven healthy domestic cats. Methods Lightly sedated normal cats were imaged pre-contrast and with microdose (0.22 ml/kg of non-ionic iodinated contrast medium, 300 mg I/ml) triple-phase MDCTA in a motion restriction device. Results On pre-contrast images, the aorta (median: 52.43 Hounsfield units [HU], range 27.35–76.74 HU) was outlined by significantly ( p  = 0.015) lower attenuating periaortic fat (−66.16 HU, −42.62 to −92.77 HU). On post-contrast images, median peak contrast enhancement in the right ventricle (111.77 HU, 36.09–141.60 HU) was achieved in 3.1 s (range 2.9–7.3 s), in the aorta (149.30 HU, 99.43–319.60 HU) and left atrium (180.83 HU, 88.53–266.84 HU) in 6.4 s (range 5.6–7.7 s) and in the left ventricle (147.89 HU, 57.23–245.77 HU) in 7.10 s (range 6.2–11.2 s). Significantly higher attenuation was measured between all chambers and walls, the right ventricular lumen and interventricular septum (median ratio 53.78 HU, range 0.21–83.20 HU), left ventricular lumen and left ventricular free wall (89.32 HU, 38.81–185.95 HU) and aorta and periaortic fat (190.43 HU, 143.22–425.44 HU) on post-contrast images. Conclusions Sufficient biological contrast is available on survey CT to discriminate between the aorta and the left atrium, and microdose MDCTA provides sufficient contrast enhancement for adequate visualization of the heart chambers in normal cats.