Toxicological Evaluation of Sleep Well Capsule

Objective: To study the acute toxicity and genetic toxicity of Sleep Wellcapsule. Methods: Rat oral acute toxicity test, genetic toxicity tests and 30-day feeding test were conducted to evaluate the safety of the capsule. Results: The maximum tolerance dose of acute toxicity test was more than 15 g/kg, indicated that the capsule was a non-toxic substance. The result of Ames test, micronucleus test and sperm deformity test was negative. The results of the 30-day feeding test in rats showed that there was no significant difference in body weight, food utilization, organ coefficients, blood routine and serum biochemical indexes between the dose group and the control group (P>0.05). Pathological changes were not shown in the main organs. Conclusion: The Sleep Wellcapsule is non - toxic, and has no genetic toxicity.