Clinical and functional features of pulmonary tuberculosis in young patients depending on the respiratory muscles strength

Measuring maximum respiratory pressure is common throughout the world to evaluate respiratory muscle function. Ineffective work of respiratory muscles can be a predictor of an infectious process in the lungs, in particular tuberculosis (TB) due to the development of inefficiency of ventilation processes. Methods: This is a prospective single center study including 84 verified TB patients from 18 to 45 years and divided for 2 groups: 1st group – 36 patients (27M/9F; 30,7±5,6yrs) with muscle disorders (MD), 2nd group - 48 control patients (26/22F; 30,7±7,17yrs) without MD. The patients after lung resection, with AIDS and diabetes were not included. Ventilation parameters we evaluted by spirometry, bodyplethysmography, diffusion capacity and respiratory muscle strength investigation - maximal inspiratory (MIP) and expiratory pressures (MEP). Descriptive statistics, Mann-Whitney test, Spearman correlation analysis were used. Results: In the 1 group MEP was decreased to 61.4±11.8% predicted; MIP – 76.2±24.2%. In the control group mean MEP was 102.2±17.2%; MIP - 86.7±25.1%. In patients with MD, the most common TB forms were disseminated, cavities - only in this group was a generalization of TB infection. The most common forms of pulmonary TB in the control group were infiltrates, tuberculoma, and only in this group, we met TB pleurisy. Patients with MD have a tendency to decrease total lung capacity (p=0.03) and vital capacity (p Conclusions: Young MD patients have more severe forms of tuberculosis. In this group, ventilation disorders tended to obstructively remodel the total lung capacity and significantly decrease MEP.