Significance of glomerular deposition of plasmin-alpha 2-plasmin inhibitor complexes in various glomerulopathies.

To elucidate the relationship between glomerular deposition of plasmin-alpha 2 -plasmin inhibitor complexes (PIC) and renal lesions or dysfunction, 25 patients with various glomerulopathies and various degrees of renal injuries were examined. Glomerular PIC deposition was found in eight patients (group A), and other 17 patients showed no deposition (group B). PIC was found mainly in the mesangium and along the capillary loops. Group A showed significantly more severe hematuria (p<0.05) than group B. Group A showed a significant decrease in glomerular filtration rate (GFR; p<0.05): the mean values being 60.8±39 in group A and 94.5±32 ml/min in group B. Group A showed a significant decrease in the phenolsulfonphthalein excretion test (p<0.05)