Efficacy analysis of amifostine combined with arsenic trioxide and vitamin C in the treatment of patients with high-risk myelodysplastic syndromes

Objective To observe the efficacy of amifostine combined with arsenic trioxide and vitamin C on patients with high-risk myelodysplastic syndromes.Methods Fifteen patients received amifostine 500 mg/d,arsenic trioxide 10 mg/d by intravenous infusion and then recieved vitamin C 2.0 g/d by intravenous infusion after 4 hours,continuous medication for 5 days a week,interval 2 days,4 weeks repeated for a course.Results Complete remission in 2 cases (13.3％),partial remission in 3 cases (20.0％),hematologic improved in 5 cases(33.3％),invalid in 5 cases(33.3％),and the total effective rate was 66.7％.Conclusions Amifostine combined with arsenic trioxide and vitamin C is effective and has no significant adverse reactions in treating high-risk myelodysplastic syndromes. Key words: Myelodysplastic syndromes ;  Amifostine ;  Arsenic trioxide ;  Vitamin C