Terahertz Nanoantenna Sensors for Detection of 2-Hydroxyglutarate Isomers in Biological Samples

Terahertz plasmonic sensors based on arrays of linear and H-shaped gold nanoantennas nanolithographically patterned on Si substrates with & without SiO 2 sublayers are numerically and experimentally studied. The sensors are optimized for the plasmonic frequencies of 1.337 and 1.695 THz corresponding to the absorption bands of L-2HG and D-2HG isomers, respectively, which act as molecular biomarkers of glioma.