Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin α5β1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity

Gang Li,Lianglin Zhang,Enhong Chen,Jianying Wang,Xin Jiang,Jeffrey H. Chen,Grant Raymond Wickman,Karin Kristina Amundson,Simon Bergqvist,James Zobel,Dana Buckman,Sangita M. Baxi,Steven Lee Bender,Gerald Fries Casperson,Dana D. Hu-Lowe

Dual Functional Monoclonal Antibody PF-04605412 Targets Integrin α5β1 and Elicits Potent Antibody-Dependent Cellular Cytotoxicity

2010

Gang Li
Lianglin Zhang
Enhong Chen
Jianying Wang
Xin Jiang
Jeffrey H. Chen
Grant Raymond Wickman
Karin Kristina Amundson
Simon Bergqvist
James Zobel
Dana Buckman
Sangita M. Baxi
Steven Lee Bender
Gerald Fries Casperson
Dana D. Hu-Lowe

Findings suggest that the efficacy of antibody-based therapy of solid tumors can be improved by engineering changes in the antibody constant region that enhance ADCC.

Keywords:

Immunology
Antibody
Antibody constant region
Antibody-dependent cell-mediated cytotoxicity
Molecular biology
Integrin
Monoclonal antibody
Medicine
Immunoglobulin G
Phagocytosis
HEK 293 cells
Haplorhini

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