Erectile dysfunction with topiramate.

The antiepileptic drug (AED) topiramate (TPM) is efficient in new-onset partial epilepsies (1) as well as in refractory partial and generalized epilepsies (2). Several adverse events with this substance have been described; the most common and important include somnolence, fatigue, nausea, anorexia and weight loss, paresthesias, psychomotor slowing and confusion, dizziness, and headache (2). Interference with sexual function with TPM has, to our knowledge, not yet been reported. We recently encountered two patients with partial epilepsy in whom reversible erectile dysfunction developed while taking TPM. We describe the cases to draw attention to a distressing side effect of the drug.