Prophylactic Application of Antibiotics during Perioperative Period in Patients Undergoing Hysterectomy

Objective To investigate the efficacy of different administration schedule of antibiotics during perioperative period in the prevention of postoperative infection in patients undergoing hysterectomy.Methods A total of 160 patients who underwent abdominal total hysterectomy for benign uterine disease were divided into four groups.The metronidazole and cefotaxime sodium were given 24 hours before operation and 3 days after operation in group A,30 minutes before operation and 3 days after operation in group B,3 days after operation in group C,and 5 days after operation in group D.Results Compared with group B,the highest temperature,antifebrile time,morbidity rates and incision infection rates significantly increased after operation in group A,C and D(P0.05),but there were no significant differences among the three groups(P0.05).In addition,no obvious differences in postope-rative adverse events were found among the four groups(P0.05).Conclusion The usage of antibiotics at 30 minutes before hysterectomy is more effective and rational than that at 24 hours before hysterectomy.And antibiotics used for more than 3 days can not decrease infection rates compared with those used for less than 3 days.