Potential driver mutations in ovarian Brenner tumors.

e22087 Background: Brenner tumors are characteristically benign ovarian neoplasms, often found in association with mucinous tumors. The pathogenesis of Brenner tumors is still unknown but it has been suggested that associated mucinous neoplasms may arise from mucinous metaplasia in the Brenner tumors, however, this has not been well characterized. To address the relationship between these coexisting neoplasms, we have run pairwise comparisons of genetic variants associated with benign Brenner tumors and ipsilateral mucinous tumors, and performed genetic profiling to identify potential driver mutations. Methods: DNA from FFPE sections of 14 ovarian tumor samples (7 benign Brenner tumors, 2 proliferating Brenner tumors, 3 mucinous cystadenoma (MCA), and 2 mucinous borderline tumors (MBT) was sequenced using the JAX Cancer Treatment Profile consisting of a 358-gene targeted panel, and submitted to the Clinical Genomics Analytical (CGA) bioinformatics pipeline. SnpEff/SnpSift variant call files were sorted ba...