A9595 Crosstalk Between Vascular Redox and Calcium Signalling in Hypertension Involves Transient Receptor Potential Melastatin 2 Channel Activation

Objectives:ROS regulates Ca2+ homeostasis by mechanisms still not fully understood. TRPM2, a redox-sensitive channel permeable to Ca2+ and Na+, is activated by H2O2 via oxidation or ADPR production. We tested the hypothesis that TRPM2 is a molecular target of ROS leading to regulation of Ca2+ levels