Clinical analysis of relationship between urinary tract infection and congenital malformalities of urinary tract in children

Objective To analyze the relationship between urinary tract infection(UTI) and congenital malformalities of urinary tract in children. Methods From January 2003 to December 2014, a total of 295 children with UTI in the First and the Fifth Affiliated Hospital of Sun Yat-sen University were included in the study. They were divided into malformalities group (n=85, with congenital malformalities of urinary tract) and non-malformation group (n=210, without congenital malformalities) according to their imageological examination results. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First Affiliated Hospital of Sun Yat-sen University and Fifth Affiliated Hospital of Sun Yat-sen University. Informed consent was obtained from each participant' parents.The clinical features were compared between two groups, including gender, age, fever, white blood cell count, erythrocyte sedimentation rate, frequency of infection, abnormal renal function and combination with other congenital malformalities. There were no significant differences between two groups in UTI severity and hospital stay(P>0.05). Results There were significant differences in gender, age≤30 days, frequency of infection(more than twice) and combination with other congenital malformalities(χ2=10.678, 4.466, 6.745, 3.466; P<0.05). The main tpye of congenital urinary tract malformalities was vesicoureteral reflux (18.8%), followed by congenital hydronephrosis (15.3%) and ureteral stricture (11.8%), etc.. Among 53 follow-up cases in malformation group, 10 cases (18.9%) underwent surgery treatment, only 1 case (1.89%) had recurrent UTI. Conclusions UTI and congenital urinary tract abnormalities are closely related in children. The children with UTI who are male, age≤30 days, with repeated UTI and combination with other malformalities are remain on high alert for congenital malformalities of urinary tract. Key words: Urologic diseases; Infection; Urogenital Abnormalities; Congenital abnormalities; Child