DYSGERMINOMA IN A PATIENT WITH PARTIAL DELETION OF X CHROMOSOME

Abnormalities involving the X chromosome have been well described. Complete monosomy X results in Turner’s syndrome. The effects of partial monosomy of the arms of the X chromosome depend on the location of the breakpoint in the arms. Accordingly, individuals affected may or may not have Turner phenotype, with or without gonadal development or function. The patients who have gonadal dysgenesis are at increased risk of development of germ cell tumors. 1 Gonadoblastomas are the most frequently occurring germ cell tumors in dysgenetic gonads with Y chromosome.