Quantification of myocardial blood flow using (201)Tl SPECT and population-based input function.

Objectives Thallium-201 (201Tl) single photon emission computed tomography (SPECT) is an important tool in the diagnosis of ischemic heart disease. Absolute quantification of myocardial blood flow (MBF) has the potential to provide more useful information on myocardial perfusion than semi-quantitative assessments. This study aimed to validate the quantification of MBF using 201Tl cardiac SPECT based on a population-averaged input function (STD-IF) and one-point blood sample technique.