18 F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18 F-FDG and 11 C-Methionine PET

Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) as a tumor-specific probe, in comparison to 18F-FDG and 11C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers.