Gail Risk Score Can Be Used in Determining the Risk of Breast Cancer in Turkish Women

PURPOSE: Breast cancer is one of the most common cancer in women. Many ways defined to determine the risk of breast cancer and the most frequently used is the Gail risk scoring. In this study, we investigated usability of Gail risk scoring to determining the risk of breast cancer for Turkish women. METHODS: Prospective study conducted between 2007-2011. Personal informations of patients who diagnosed of breast cancer and controlled for the breast disease by outpatient collected. Gail risk scores of the patients calculated by using breast cancer risk assessment tool in the wepsite of ‘www.cancer.gov/bcrisktool’. Previously diagnosed with breast cancer follow-up outpatients were excluded. Breast cancer diagnosed patient’s last diagnostic biopsies were excluded from the calculation. Statistically, P<0.05 was considered significant. Dependence between categorical variables were evaluated with chi-square test. RESULTS: In this study, 709 women have been included, diagnosed breast cancer patients were 236(%33.3) and follow-up outpatients were 473(%66.7). The average age of total patients was 48.716(35-85) year. The average age was 52.68(35-85)year in diagnosed with breast cancer group and 46.33(35-82)year follow-up outpatients group. After the calculation of Gail risk score there were 98(%13.8) patients in the risk group and scores were above the critical value of 1.7. There were 45(45.91) followed outpatients and 53(%54.09) breast cancer diagnosed patients in the risk group. Breast cancer diagnosed one or more relatives rate was %12.3 and none was %87.7 in the family of followed-up outpatients group. The rate was %14.7 and %85.3 in the breast cancer diagnosed group, respectively. There was no significant differences between the two groups statistically. There was no significant differences between the two groups for results obtained from the other parameters of calculated Gail risk score. DISCUSSION: For women with gail risk score above 1.7 are recommended close follow-up or prophylactic preventions. But there was no differences between two groups (follow-up outpatients and breast cancer diagnosed patients) of Gail risk scores above the critical value of 1.7 statistically. Gail risk score is not enough for determine the risk group of breast cancer in Turkish women. A new risk calculation model should be developed for the Turkish women obtained data from multi-center studies.