Peritoneal Mesothelioma Associated with Polyclonal Hyperimmunoglobulinemia

This patient had marked polyclonal hyperimmunoglobulinemia associated with mesothelioma in the right sub-phrenic space. Histopathologically the lymph nodes around the mesothelioma showed marked plasma cell proliferation intermingled with infiltration of mesothelioma cells. The plasma cell proliferation was observed even in distant lymph nodes not infiltrated by the tumor cells. The review of the literature disclosed rather frequent occurrences of hyperimmunoglobulinemia in mesothelioma and significance of this association should be stressed.