COVID-19 in kidney transplant recipients: Experience from a large health system in Louisiana

Background: Infections are an important cause of morbidity and mortality among kidney transplant recipients The novel Coronavirus Disease 2019 (COVID-19) has affected all kinds of populations world-wide However, the role of immunosuppression in the outcomes of these patients is not well understood Methods: We conducted a retrospective study in kidney transplant recipients from a single health system that were diagnosed with COVID-19 based on a positive real-time reverse transcription polymerase chain reaction test for SARS-CoV-2 RNA between 03/01/2020 and 04/30/2020 We compared them with affected patients without a kidney transplant and without any kind of immunosuppressive medication (control) We examined the rates of hospitalization, intensive-care unit (ICU) admission, acute kidney injury (AKI) and mortality as outcome measures Results: A total of 8473 patients were diagnosed with COVID-19 within our Health System within the study period Thirty-three (0 4%) were kidney transplant recipients Sixteen of the 33 (48%) were admitted to the hospital (median age of 56, 68% males, 93% African American) vs 2201 admissions (25%) for the control group (median age 66, 48% males, 65% African-American), i e , a significantly greater risk for hospitalization for transplant recipients (p = 0 002) Percentage of patients with hypertension in the transplant group was numerically higher (93% vs 80%, p = 0 06), as well as the number of ICU admissions (43% vs 28%, p = 0 055) AKI was more common in transplant patients (81% vs 33 8% p<0 0001) No difference in mortality was observed (31 vs 24%, p = 0 34) Among transplant patients, those hospitalized were more likely to be on prednisone (75% vs 35%, p = 0 025) and had a post-transplant graft life of 7 9 years compared to 5 5 years for those not hospitalized, p 0 08) Conclusions: Kidney transplant recipients affected with COVID-19 exhibited a greater incidence of hospitalization, AKI and a trend for more ICU admissions Use of immunosuppression with prednisone was associated with greater risk for hospitalization