T-Cell Receptor-γ in Gamma-Delta Phenotype Cutaneous T-Cell Lymphoma Can Be Accompanied by Atypical Expression of CD30, CD4, or TCRβF1 and an Indolent Clinical Course

clinical features were heterogeneous, and the diagnosis of CGDTCL was based on extensive immunophenotypic characterization, including T-cell receptor (TCR)-g expression. The novel finding of this study is the presence of unusual immunophenotypical profiles in most of these patients, including CD4-postive (CD4 þ ), CD30 þ or TCR-bF1 þ , which are typical of less aggressive cutaneous T-cell lymphoma (TCL). In the minority of cases, with the classic CGDTCL immunophenotype profile, aggressive therapy initiated early induced resolution of lesions in 1 patient. Our data suggest that CGDTCLs diagnosed according to TCRg expression are not always associated with the aggressive phenotype. These findings call into question the diagnostic power of TCRg alone as a marker of CGDTCL, especially in cases where certain immune markers are also present. The presence of these markers might explain the indolent disease course in these patients.