Effect of itraconazole on the pharmacokinetics of bupivacaine enantiomers in healthy volunteers.
1999
We studied seven healthy volunteers given itraconazole 200 mg orally or placebo, once daily for 4 days, in a crossover study. On day 4, racemic bupivacaine 0.3 mg kg-1 was given i.v. over 60 min and venous plasma samples were collected for 23 h. Plasma concentrations of R- and S-bupivacaine, itraconazole and hydroxyitraconazole were measured. Itraconazole reduced the clearance of R-bupivacaine by 21% (P
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
6
References
19
Citations
NaN
KQI