Therapeutic effect of high frequency oscillatory ventilation on neonatal bronchopulmonary dysplasia

Objective To observe and evaluate the clinical effects of high frequency oscillatory ventilation (HFOV) in the treatment of neonatal bronchopulmonary dysplasia (BPD). Methods From June 2017 to February 2019, 82 children with neonatal bronchopulmonary dysplasia (BPD) admitted to the Department of Pediatrics of Huidong County People's Hospital and Huizhou Central People's Hospital were randomly divided into two groups. 41 children in the control group received conventional continuous positive airway pressure therapy; 41 children in the observation group were treated with high-frequency oscillatory ventilation. The clinical effects of the two groups were compared. Results The oxygen exposure time and mechanical ventilation time of the observation group were significantly lower than those of the control group (t=43.302 7, 21.822 6, P 0.05). The OI values of the observation group and the control group at 48 hours after treatment were significantly lower than those before treatment (t=6.523 8, 4.304 7, P<0.05); the OI value of the observation group at 48 hours after treatment was significantly lower than that of the control group (t=3.665 2, P<0.05). The incidence of complications of the observation group was 4.88%, which was significantly lower than that of the control group (29.27%) (χ2=8.613 4, P<0.05). Conclusion High frequency oscillatory ventilation (HFOV) can significantly improve the oxygenation index for children with bronchopulmonary dysplasia (BPD), shorten the oxygen exposure time and mechanical ventilation time, and effectively reduce the occurrence of complications, which is worthy of clinical promotion and application. Key words: Neonates; Bronchopulmonary dysplasia; High frequency oscillatory ventilation; Continuous positive airway pressure